Design and implementation of a sub-threshold wireless BFSK transmitter

Power Consumption in VLSI (Very Large Scale Integrated) circuits is currently a major issue in the semiconductor industry. Power is a first order design constraint in many applications. Several of these applications need extreme low power but do not need high speed. Sub-threshold circuit design can be used in these cases, but at such a low supply voltage these circuits exhibit an exponential sensitivity to process, voltage and temperature (PVT) variations. In this thesis we implement and test a robust sub-threshold design flow which uses circuit level PVT compensation to stabilize circuit performance. This is done by dynamic modulation of the delay of a representative signal in the circuit and then phase locking it with an external reference signal. We design and fabricate a sub-threshold wireless BFSK transmitter chip. The transmitter is specified to transmit baseband signals up to a data rate of 32kbps over a distance of 1000m. In addition to the sub-threshold implementation, we implement the BFSK transmitter using a standard cell methodology on the same die operating at super-threshold voltages on a different voltage domain. Experiments using the fabricated die show that the sub-threshold circuit consumes 19.4x lower power than the traditional standard cell based implementation

External validation and recalibration of an incidental meningioma prognostic model - IMPACT: protocol for an international multicentre retrospective cohort study

Introduction: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an estimated prevalence of 3/1000. The management of incidental meningioma varies widely with active clinical-radiological monitoring being the most accepted method by clinicians. Duration of monitoring and time intervals for assessment, however, are not well defined. To this end, we have recently developed a statistical model of progression risk based on single-centre retrospective data. The model Incidental Meningioma: Prognostic Analysis Using Patient Comorbidity and MRI Tests (IMPACT) employs baseline clinical and imaging features to categorise the patient with an incidental meningioma into one of three risk groups: low, medium and high risk with a proposed active monitoring strategy based on the risk and temporal trajectory of progression, accounting for actuarial life expectancy. The primary aim of this study is to assess the external validity of this model. Methods and analysis: IMPACT is a retrospective multicentre study which will aim to include 1500 patients with an incidental intracranial meningioma, powered to detect a 10% progression risk. Adult patients ≥16 years diagnosed with an incidental meningioma between 1 January 2009 and 31 December 2010 will be included. Clinical and radiological data will be collected longitudinally until the patient reaches one of the study endpoints: intervention (surgery, stereotactic radiosurgery or fractionated radiotherapy), mortality or last date of follow-up. Data will be uploaded to an online Research Electronic Data Capture database with no unique identifiers. External validity of IMPACT will be tested using established statistical methods. Ethics and dissemination: Local institutional approval at each participating centre will be required. Results of the study will be reported through peer-reviewed articles and conferences and disseminated to participating centres, patients and the public using social media